SERUM PROTEOMIC PROFILING OF PRECANCEROUS GASTRIC LESIONS AND EARLY GASTRIC CANCER REVEALS SIGNATURES ASSOCIATED WITH SYSTEMIC INFLAMMATORY RESPONSE AND METAPLASTIC DIFFERENTIATION

The noninvasive detection technique using serum for large-scale screening is useful for the early diagnosis of gastric cancer (GC).Herein, we employed liquid chromatography mass spectrometry to determine the serum proteome signatures and related pathways in individuals with gastric precancerous (pre-GC) lesions and GC and explore the effect of Heli

Pathological abnormalities in the tau protein give rise to a variety of neurodegenerative diseases, conjointly termed tauopathies.Several tau mutations have been identified in the tau-encoding gene MAPT, affecting either the physical properties of tau or resulting in altered tau splicing.At early disease stages, mitochondrial dysfunction was highli

ABSTRACT Objective: The aim of this study was to compare the occlusal changes of rapid maxillary expansion (RME) and slow maxillary expansion (SME) in patients with unilateral complete cleft Optic Accessories lip and palate (UCLP), by means of digital dental models.Methods: Group RME was composed by 22 patients (13 males and 9 females), with mean a

Chronic kidney disease (CKD) is associated with an enhanced oxidative stress and deep modifications in lipid and lipoprotein metabolism.First, many oxidized lipids accumulate in CKD and were Western Reins shown to exert toxic effects on cells and tissues.These lipids are known to interfere with many cell functions and to be pro-apoptotic and pro-in

Prism adaptation improves a wide range of manifestations of left spatial neglect in right-brain-damaged patients.The typical paradigm consists of repeated pointing movements to visual targets, while patients wear prism goggles that displace the visual scene rightwards.Recently, we demonstrated the efficacy of a novel adaptation procedure, involving